Kilmar Abrego Garcia has been taken into custody after arriving at a US Immigration and Customs Enforcement (ICE) office in Baltimore.
In a statement, Secretary of Homeland Security Kristi Noem confirmed his arrest and said that ICE "are processing him for deportation”.
He was mistakenly deported to a notorious prison in El Salvador in March, and then brought back to face criminal charges.
US authorities have informed him he may be deported to Uganda, following his refusal to accept a plea deal, his lawyers say.
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